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AICAR Overview - WHAT IS AICAR?
5-Aminoimidazole-4-carboxamide ribonucleotide, AICAR for short, it is an analog of AMP (adenosine monophosphate), which stimulates AMPK (AMP-dependent protein kinase) processes in the body. As a matter of fact, AICAR works best as part of an endurance stack, and it has been used by athletes as a performance enhancing compound in sports, where endurance is needed. We are offering AICAR in raw powder form.
AICAR (powder) Details: CAS ID: 2627-69-2 Synonyms: Acadesine; Aminoimidazole carboxamide ribonucleotide; AICA ribonucleotide; ZMP; 5-Amino-1-β-D-ribofuranosyl-imidazole-4-carboxamide. Molecular Formula: C9H15N4O8P Molecular Weight: 338.211162 Appearance: White Powder Purity: 99.21% Melting point: 213-214 °C Storage: Before reconstitution (lyophilized / freeze dried powder): Can be stored in the refrigerator (2°C to 8°C = 35°F to 47°F) for 36 months. Can be stored at room Temperature (up to 37°C = 99°F) for 90 days. After reconstitution (liquid): Can be stored in the refrigerator (2°C to 8°C = 35°F to 47°F) for 5 days. Transportion time at room temperature has not effect on product quality degradation.
Solubility: Soluble in DMSO (15 mg/ml); or water (15 mg/ml).
AICAR will trigger AMP activated protein kinase (AMPK), leading to glucose uptake by cells of skeletal muscle. In fact, The Howard Hughes Medical Center and Salk Institute ran a series of experiments with AICAR in the 2000’s. In these studies they found out that mice that were given AICAR could run 44% further, even without training for it. Consequently, once endurance athletes got word of this amazing compound, AICAR was being used without any regulation or fear of testing until 2011.
AICAR works by stimulating the glucose uptake and increasing the activity of p38 mitogen-activated protein kinases a and b in skeletal muscle tissue. Additionally, its reduction of reactive oxygen compounds within cells suppresses apoptosis; that is, the process of programmed cellular death that may occur in animal test subjects. In other words, it increases the type of fuel responsible for the maintenance and regulation of skeletal muscle tissue while prolonging the life of cells.
The functionality of AICAR was pinpointed during extensive research conducted by the Salk Institute in 2008, when it conducted a battery of studies on laboratory rats. According to this particular research, it was determined that the mice that were given AICAR exhibited a significant improvement concerning endurance-type exercise. While the mechanics of this particular improvement were not isolated and specified, it was theorized that it was due to AICAR's facility for converting fast-twitch muscle fibers to slow-twitch muscle fibers. This conversion in turn allowed for a much higher rate of energy efficiency amongst the lab rats. Additionally, the scientific tests noted that the conversion also allowed for a more efficient fat burning process amongst the animal test subjects.
AICAR STACKING WITH GW-501516
Both AICAR and GW 501516 (cardarine) are on WADA’s banned substances list, and if used together they make a potent endurance stack. One of the differences between the two is that GW501516 is a PPAR-delta agonist, while AICAR is a PPAR-delta AMPK axis agonist.
In terms of doping, GW is easily detectable for up to 40 days in urine tests, as it is not a naturally occuring substance in the body. Meanwhile, AICAR is a naturally occuring substance in the body, so this makes it more difficult to test for. To combat this, a baseline value was established, which determines if someone is using AICAR to dope with. Nevertheless, it has still been proven to be harder to catch cheaters using AICAR than GW. For instance, a Spanish team cycling doctor was caught with AICAR in his luggage, so we know cyclists are using it - they just aren’t getting caught.
The final major difference is that AICAR is extremely pricey when compared to GW. Kindly check the prices comparison of AICAR and GW 501516 powder. Check the full price list on our homepage.